The Sustainable Manufacturing Systems Research Laboratory (SMSRL) works on various research areas including joint production and energy system modeling and control, real-time energy management of manufacturing systems, electricity demand response of manufacturing systems,  electric vehicle battery manufacturing and reliability assessment, system-level cost evaluation for  cellulosic biofuel manufacturing, and intelligent maintenance of manufacturing systems. The extension of engineering research to healthcare system is also an important research direction of the laboratory.

The Laboratory has received significant research funding from the NSF, DOE, General Motors, Eaton Corporation, General Electric and other collaborators.